Professors John Teasdale, Mark Williams, and Zindel Segal developed the MBCT program. They have conjectured that MBCT (and mindful responding) may work by helping people change the way in which they respond to negative thoughts and feelings. This new mode is called distancing, and allows thoughts and feelings to be experienced as passing events, rather than experiences that reflect personally on one's sense of self-worth, or which require unhelpful reactions or behaviours. Individuals can then use mindfulness to disengage from unhelpful and somewhat automatic responses when negative moods and thinking arise, and engage in more helpful ways of responding which can help prevent the spiral of negative thinking and mood that can lead to depression.
A number of randomised controlled trials (listed below) provide strong scientific support for the efficacy of MBCT for helping to prevent depression relapse in adult populations once they have recovered or partially recovered from a depressive episode. At the present time this form of therapy is indicated for people that have experienced 3 or more depressive episodes. It is not recommended as a treatment for acute depression or single episode depression, and in some cases may be counterproductive. When depression occurs concentration reduces, making it difficult for patients to engage in MBCT effectively. However, some preliminary research suggests it may have some benefits for adults with treatment resistant depression, outpatients with mild to moderate mood problems, and for reducing depression and anxiety in bipolar patients that are stablised in mood. Although, much more research is needed before strong conclusions can be drawn.